5-MTHF 1mg

What Is 5-MTHF 1mg?

5-MTHF 1mg by Thorne delivers 1mg of 5-methyltetrahydrofolate — the biologically active form of folate (vitamin B9) that your body uses directly, without requiring conversion by the MTHFR enzyme. A significant portion of the population carries MTHFR gene variants that reduce their ability to convert dietary folic acid into active 5-MTHF, meaning standard folic acid supplements provide limited benefit for these individuals. By delivering folate in its ready-to-use methylated form, this supplement ensures full folate activity regardless of genetic status. 60 capsules per bottle.

Key Benefits

• Provides bioavailable folate that bypasses the MTHFR enzyme conversion step — essential for MTHFR gene variant carriers
• Supports healthy cardiovascular function through homocysteine metabolism regulation
• Promotes healthy neurological function, mood balance, and neurotransmitter synthesis through methylation support
• Supports DNA synthesis, repair, and proper cell division throughout the body
• Critical for prenatal and preconception health — supports healthy fetal neural tube development
• Helps maintain healthy methylation pathways that regulate hundreds of biochemical reactions in the body

Who Should Take This?

5-MTHF 1mg is particularly important for individuals with known MTHFR gene variants (C677T or A1298C), women of childbearing age and those who are pregnant or planning pregnancy, patients with elevated homocysteine levels, individuals with depression or mood imbalances that may have a methylation component, and anyone taking methotrexate or other folate-depleting medications. Our doctors recommend MTHFR testing for many patients given the prevalence of this variant and its broad health implications.

How to Use

• Serving size: Take 1 capsule daily, or as directed by your healthcare provider
• Timing: Can be taken at any time with or without food; often taken in the morning alongside other foundational supplements
• Duration: Suitable for ongoing daily use, particularly for those with MTHFR variants or ongoing prenatal/preconception support needs
• Stacking: Works synergistically with B-Complex #12 (which includes 5-MTHF and methylated B12), Magnesium Bisglycinate for methylation cofactor support, and Basic Nutrients 2/Day for comprehensive foundational coverage

Our Doctors’ Take

Our doctors consider methylation support one of the most underappreciated aspects of foundational health. MTHFR variants are remarkably common — estimates suggest 40-60% of the general population carries at least one copy — and the downstream effects on cardiovascular health, mood, energy, and reproductive health are significant. The simple switch from synthetic folic acid to bioactive 5-MTHF is one of the highest-leverage supplement changes we recommend, especially for patients with a family history of cardiovascular disease or those dealing with treatment-resistant mood challenges.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.