What Is PurePath Microbiome Support?
PurePath Microbiome Support delivers 10 Billion CFU of Saccharomyces boulardii, a clinically researched probiotic yeast with a distinct mechanism of action from standard bacterial probiotics. Unlike Lactobacillus or Bifidobacterium strains, S. boulardii is a yeast-based organism that is naturally resistant to antibiotics โ making it uniquely valuable for restoring and protecting intestinal flora balance during or after antibiotic therapy, travel, or GI disturbance. It supports the gut barrier, modulates immune function in the intestine, and helps crowd out opportunistic organisms that can take hold when the microbiome is compromised.*
Key Benefits
- Delivers 10 Billion CFU of clinically studied Saccharomyces boulardii per serving*
- Supports healthy gut flora balance during and after antibiotic use*
- Promotes intestinal barrier integrity and mucosal immune function*
- May help support healthy bowel regularity and reduce digestive discomfort*
- Naturally antibiotic-resistant โ effective even when taken alongside antibiotics*
- Supports immune system function via the gut-immune axis*
Who Should Take This?
PurePath Microbiome Support is especially well-suited for individuals currently taking or recently completing a course of antibiotics, those who have experienced traveler’s diarrhea or foodborne illness, and patients with a history of recurring gut disturbances. It is also a strong complement to the MaxLiving 4R Gut Protocol as a targeted microbiome restoration tool. Our doctors recommend it as a distinct option from multi-strain probiotics for its unique targeted properties.*
How to Use
- Serving size: Follow label instructions (typically 1-2 capsules daily)
- Timing: Can be taken with or without food; if using alongside antibiotics, space doses at least 2 hours apart from the antibiotic dose
- Duration: Recommended for the full duration of antibiotic therapy plus 2-4 weeks afterward; or as directed by your doctor for ongoing microbiome support
- Stacking: Pairs well with GI Replenish (multi-strain probiotic) for comprehensive microbiome restoration, and PurePath GI Repair for gut lining support during recovery
Our Doctors’ Take
S. boulardii is one of those supplements that has exceptional clinical research behind it and yet most people have never heard of it. The fact that it is antibiotic-resistant means you can actually use it during treatment to minimize the collateral damage to your microbiome โ that is something no bacterial probiotic can offer. For our patients going through antibiotic courses or recovering from significant GI disruption, this is one of the first things we reach for.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



















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